Abstract
The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.
Keywords: muscarinic receptors, allosterism, cooperativity, enhancers, receptor models, structure-activity relationships, interaction studies, receptor subtype selectivity
Mini-Reviews in Medicinal Chemistry
Title: Allosterism at Muscarinic Receptors: Ligands and Mechanisms
Volume: 5 Issue: 6
Author(s): N. J.M. Birdsall and S. Lazareno
Affiliation:
Keywords: muscarinic receptors, allosterism, cooperativity, enhancers, receptor models, structure-activity relationships, interaction studies, receptor subtype selectivity
Abstract: The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.
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Cite this article as:
Birdsall J.M. N. and Lazareno S., Allosterism at Muscarinic Receptors: Ligands and Mechanisms, Mini-Reviews in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1389557054023251
DOI https://dx.doi.org/10.2174/1389557054023251 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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