Allosterism at Muscarinic Receptors: Ligands and Mechanisms

Author(s): N. J.M. Birdsall, S. Lazareno

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 6 , 2005

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The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

Keywords: muscarinic receptors, allosterism, cooperativity, enhancers, receptor models, structure-activity relationships, interaction studies, receptor subtype selectivity

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Article Details

Year: 2005
Page: [523 - 543]
Pages: 21
DOI: 10.2174/1389557054023251
Price: $65

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PDF: 19