AMPA Receptor Antagonists as Potential Anticonvulsant Drugs

Author(s): Giovambattista De Sarro, Rosaria Gitto, Emilio Russo, Guido Ferreri Ibbadu, Maria Letizia Barreca, Laura De Luca, Alba Chimirri

Journal Name: Current Topics in Medicinal Chemistry

Volume 5 , Issue 1 , 2005

Become EABM
Become Reviewer
Call for Editor


Over the last years α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) have been intensively studied owing to their crucial role in physiological and pathological processes. Efforts targeting AMPAR have been focused on identification of ligands as potential therapeutic agents useful in the prevention and treatment of a variety of neurological and non-neurological diseases. In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents.

Keywords: glutamate, ampa receptor antagonists, ampar, anticonvulsants

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2005
Published on: 01 March, 2012
Page: [31 - 42]
Pages: 12
DOI: 10.2174/1568026053386999

Article Metrics

PDF: 26