Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 2 (mGluR2)

Author(s): Michael T. Rudd, John A. McCauley

Journal Name: Current Topics in Medicinal Chemistry

Volume 5 , Issue 9 , 2005

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This article describes recent medicinal chemistry progress toward selective potentiators of the metabotropic glutamate receptor 2 (mGluR2). Groups at Lilly and Merck have identified new classes of potentiators that exhibit selectivity for mGluR2 over the seven other subtypes of mGluRs. Structure-activity relationships as well as pharmacokinetic properties and in vivo activity are reviewed.

Keywords: glutamate, mglur, group II, potentiator, agonist

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Article Details

Year: 2005
Page: [869 - 884]
Pages: 16
DOI: 10.2174/1568026054750281
Price: $65

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