Title: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 2 (mGluR2)
VOLUME: 5 ISSUE: 9
Author(s):Michael T. Rudd and John A. McCauley
Affiliation:Department of Medicinal Chemistry, Merck Research Laboratories, WP14-3, Merck&Co., Inc., POBox 4, West Point, PA 19486 USA.
Keywords:glutamate, mglur, group II, potentiator, agonist
Abstract: This article describes recent medicinal chemistry progress toward selective potentiators of the metabotropic glutamate receptor 2 (mGluR2). Groups at Lilly and Merck have identified new classes of potentiators that exhibit selectivity for mGluR2 over the seven other subtypes of mGluRs. Structure-activity relationships as well as pharmacokinetic properties and in vivo activity are reviewed.
