Synthesis and Pharmacology of New Camptothecin Drugs

Author(s): Russell W. Driver, Li-Xi Yang

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 5 , 2005

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Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.

Keywords: camptothecin, homocamptothecin, silatecan, pharmacology, synthesis

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Article Details

Year: 2005
Published on: 01 March, 2012
Page: [425 - 439]
Pages: 15
DOI: 10.2174/1389557053765547
Price: $65

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