Effect of Additional Chiral Ligands in Catalytic Enantioselective Addition of Ketene Silyl Acetals to Nitrones

Author(s): P. Merino, S. Franco, P. Jimenez, T. Tejero, M. A. Chiacchio

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 4 , 2005

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Abstract:

The enantioselectivity of the titanium (IV)-BINOL catalyzed asymmetric Mannich-type reactions of nitrones can be enhanced by using additional chiral ligands. The best results are obtained with diols derived from D-mannitol.

Keywords: nitrones, hydroxylamines, aminoacids, mannich reaction

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2005
Page: [302 - 305]
Pages: 4
DOI: 10.2174/1570178054038803
Price: $65

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