Abstract
This review discusses structural aspects of second-generation KATP channel openers (KCOs), which exhibit improved tissue-selectivity. Their therapeutic profile is debated with main focus on cardiac ischemia, asthma, and urinary incontinence.
Keywords: katp channel openers (kcos), benzopyrans, cyclobutenediones, dihydropyridine related structures, tertiary carbinols, structure-activity relationships, therapeutic potential, myocardial ischemia, asthma, urinary incontinence
Mini-Reviews in Medicinal Chemistry
Title: Second-Generation KATP Channel Openers
Volume: 5 Issue: 11
Author(s): Raimund Mannhold and Gerard Leclerc
Affiliation:
Keywords: katp channel openers (kcos), benzopyrans, cyclobutenediones, dihydropyridine related structures, tertiary carbinols, structure-activity relationships, therapeutic potential, myocardial ischemia, asthma, urinary incontinence
Abstract: This review discusses structural aspects of second-generation KATP channel openers (KCOs), which exhibit improved tissue-selectivity. Their therapeutic profile is debated with main focus on cardiac ischemia, asthma, and urinary incontinence.
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Cite this article as:
Mannhold Raimund and Leclerc Gerard, Second-Generation KATP Channel Openers, Mini-Reviews in Medicinal Chemistry 2005; 5 (11) . https://dx.doi.org/10.2174/138955705774575282
DOI https://dx.doi.org/10.2174/138955705774575282 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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