Title: Second-Generation KATP Channel Openers
VOLUME: 5 ISSUE: 11
Author(s):Raimund Mannhold and Gerard Leclerc
Affiliation:Department of Laser Medicine, Molecular Drug Research Group, Heinrich-Heine-Universitat, Universitatsstraße 1, 40225 Dusseldorf, Germany.
Keywords:katp channel openers (kcos), benzopyrans, cyclobutenediones, dihydropyridine related structures, tertiary carbinols, structure-activity relationships, therapeutic potential, myocardial ischemia, asthma, urinary incontinence
Abstract: This review discusses structural aspects of second-generation KATP channel openers (KCOs), which exhibit improved tissue-selectivity. Their therapeutic profile is debated with main focus on cardiac ischemia, asthma, and urinary incontinence.
