The Brown Adipose Cell: A Unique Model for Understanding the Molecular Mechanism of Insulin Resistance

Author(s): Angela M. Valverde, Manuel Benito

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 3 , 2005

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Type 2 diabetes mellitus (NIDDM) is a complex metabolic disease that occurs when insulin secretion can no longer compensate insulin resistance in peripheral tissues. At the molecular level, insulin resistance correlates with impaired insulin signaling. This review provides new insights into the molecular mechanisms of insulin action and resistance in brown adipose tissue (BAT) and pinpoints the role of BAT in the control of glucose homeostasis.

Keywords: brown adipocytes, insulin signaling, insulin resistance, insulin receptor, insulin receptor substrates, adipocyte differentiation

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Article Details

Year: 2005
Page: [269 - 278]
Pages: 10
DOI: 10.2174/1389557053175380
Price: $65

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