Abstract
The primary function of the renin-angiotensin system (RAS) is to maintain fluid homeostasis and regulate blood pressure. Several components of the RAS, namely angiotensinogen, angiotensin converting enzyme, angiotensin II and their receptors, are found in the CNS suggesting the possibility of a localized RAS in the brain. Cognitively disabling neurodegenerative disorders such as Alzheimers disease or vascular dementia show vascular lesions, and the brain RAS has been suggested to contribute to the disease process. The aim of this brief review is to summarize the current state of research in this field with emphasis on RAS-related alterations during the course of neurodegenerative disorders.
Keywords: renin-angiotensin system, angiotensin II, III, IV, angiotensin converting enzyme, at1 and at2 receptors, alzheimer's disease dementia
Current Alzheimer Research
Title: The Role of the Brain Renin-Angiotensin System in Neurodegenerative Disorders
Volume: 2 Issue: 1
Author(s): Egemen Savaskan
Affiliation:
Keywords: renin-angiotensin system, angiotensin II, III, IV, angiotensin converting enzyme, at1 and at2 receptors, alzheimer's disease dementia
Abstract: The primary function of the renin-angiotensin system (RAS) is to maintain fluid homeostasis and regulate blood pressure. Several components of the RAS, namely angiotensinogen, angiotensin converting enzyme, angiotensin II and their receptors, are found in the CNS suggesting the possibility of a localized RAS in the brain. Cognitively disabling neurodegenerative disorders such as Alzheimers disease or vascular dementia show vascular lesions, and the brain RAS has been suggested to contribute to the disease process. The aim of this brief review is to summarize the current state of research in this field with emphasis on RAS-related alterations during the course of neurodegenerative disorders.
Export Options
About this article
Cite this article as:
Savaskan Egemen, The Role of the Brain Renin-Angiotensin System in Neurodegenerative Disorders, Current Alzheimer Research 2005; 2 (1) . https://dx.doi.org/10.2174/1567205052772740
DOI https://dx.doi.org/10.2174/1567205052772740 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Proteomics Analysis of CA1 Region of the Hippocampus in Pre-, Progression and Pathological Stages in a Mouse Model of the Alzheimer’s Disease
Current Alzheimer Research Patterns of Gray and White Matter Changes in Individuals at Risk for Alzheimer’s Disease
Current Alzheimer Research Dendrimers as Novel Systems for Delivery of Neuropharmaceuticals to the Brain
CNS & Neurological Disorders - Drug Targets Polyphenols in Disease: from Diet to Supplements
Current Pharmaceutical Biotechnology Opiate Drug Use and the Pathophysiology of NeuroAIDS
Current HIV Research Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30
Current Alzheimer Research The Premature Lottery in the Canadian Grey Zones
Current Pediatric Reviews The Prevention of Adverse Drug Reactions in Older Subjects
Current Drug Metabolism Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases
Current Drug Targets Mass Spectrometric Imaging of the Nervous System
Current Pharmaceutical Design Neurotransmitter Effects in Human Immunodeficiency Virus (HIV) and Simian Immuno-Deficiency Virus (SIV) Infection
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Arachidonate Cascade in the Intensive Insulin Therapy for Critically Ill Patients with Sepsis: Roles of Prostaglandins on Hyperglycemia-Impaired Immunity
Letters in Drug Design & Discovery Alzheimers Disease and Intelligence
Current Alzheimer Research Peripheral Blood Mononuclear Cells of Alzheimer's Disease Patients Control CCL4 and CXCL10 Levels in a Human Blood Brain Barrier Model
Current Alzheimer Research Neuroimaging Correlates of 22q11.2 Deletion Syndrome: Implications for Schizophrenia Research
Current Topics in Medicinal Chemistry 2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery
Current Medicinal Chemistry Fast Dissolving Films: A Review
Current Drug Delivery Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential
Current Alzheimer Research The Role of Glucose in the Pathogenesis of Alzheimers Disease Revisited:What Does it Tell us About the Therapeutic use of Lithium?
Central Nervous System Agents in Medicinal Chemistry Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward
Current Alzheimer Research