Structure-Activity Relationship Within the Serine Protease Inhibitors of the Pacifastin Family

Author(s): Christine Kellenberger, Alain Roussel

Journal Name: Protein & Peptide Letters

Volume 12 , Issue 5 , 2005


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Abstract:

The members of the Pacifastin family are serine protease inhibitors found in insects and crustacean. They are either small inhibitors (made of one consensus cysteine-rich motif) or proteins (4-9 motifs). Some of these inhibitors are characterized by a species selectivity for the trypsin inhibition. Structural data discriminate the small inhibitors that apparently look very similar into two groups. Interestingly, the inhibitors that display species selectivity fall in the same structural group.

Keywords: pacifastin, protease inhibitor, insect, structure, species selectivity

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2005
Page: [409 - 414]
Pages: 6
DOI: 10.2174/0929866054395239
Price: $65

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