From the Discovery of the Reactive Site of Inhibitors to Their Sequence to Reactivity Algorithm

Author(s): M. A. Qasim

Journal Name: Protein & Peptide Letters

Volume 12 , Issue 5 , 2005


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Abstract:

Michael Laskowski Jr. (1930-2004) was a pioneer in the field of Standard mechanism serine proteinase inhibitors. He made numerous important contributions in the field. This article highlights some of his most important contributions such as the discovery of the reactive site in serine proteinase inhibitors, the proposal of the Standard mechanism of inhibition, and the sequence to reactivity algorithm for the Kazal family of inhibitors.

Keywords: proteinase inhibitors, spectroscopy, thermodynamics, reactive site residue, chymotrypsin

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2005
Published on: 01 March, 2012
Page: [397 - 401]
Pages: 5
DOI: 10.2174/0929866054395347
Price: $65

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