Tetrabutylammonium Hydrogensulphate Catalyzed Efficient Synthesis of Glycosyl(aryl) Dihydropyrimidinones

Author(s): N. Dwivedi, R. C. Mishra, R. P. Tripathi

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 5 , 2005

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Abstract:

An efficient synthesis of glycosyl dihydropyrimidinones using a three-component reaction of a α- keto ester, glycosyl aldehyde, urea (or thiourea) in the presence of tetrabutylammonium hydrogensulphate and diethylene glycol as eco-friendly solvent has been reported. The reaction has been extended to the synthesis of aryl dihydropyrimidinones also. The glycosyl dihydropyrimidinones were obtained in excellent yields in less time than the methods already reported.

Keywords: aldehydes, phase transfer catalyst, dihydropyrimidinone

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Article Details

VOLUME: 2
ISSUE: 5
Year: 2005
Page: [450 - 457]
Pages: 8
DOI: 10.2174/1570178054405986
Price: $65

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