Three Components Coupling Catalysed by Na2CaP2O7: Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions at Room Temperature

Author(s): M. Zahouily, A. Elmakssoudi, A. Mezdar, A. Rayadh, S. Sebti, H. B. Lazrek

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 5 , 2005

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Synthetic phosphate Na2CaP2O7 has been utilized as an efficient catalyst for the three components coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphite to produce α-amino phosphonates. The reaction was carried out under solvent-free conditions at room temperature. The by-product H2O formed during the reaction increases the catalytic activity of Na2CaP2O7.

Keywords: synthetic phosphate, amino phosphonates, heterogeneous catalysis, recyclable catalyst

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Article Details

Year: 2005
Page: [428 - 432]
Pages: 5
DOI: 10.2174/1570178054405887
Price: $65

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