A Facile Synthesis for Novel Pyrimido[1,3,4]Triazepine

Author(s): M. Kidwai, K. Singhal, R. Thakur

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 5 , 2005

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Abstract:

An efficient route to the synthesis of novel fused pyrimidotriazepine derivatives using inorganic solid supports under MWs is described herein. The methodology uses microwave as an alternative heating source, which eliminates the usage of solvent during the course of reaction. With this environmentally benign approach, the reaction time is brought down from hours to minutes along with the yield enhancement. In addition, the catalytic role of different inorganic supports is studied for this [2+5] condensation reaction and montmorillonite K-10 clay is found to be the best solid support in terms of catalyst as well as an energy transfer medium.

Keywords: pyrimidotriazepine, thiosemicarbazone, thiobarbituric acid, microwave, solid support, montmorillonite k clay

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Article Details

VOLUME: 2
ISSUE: 5
Year: 2005
Page: [419 - 423]
Pages: 5
DOI: 10.2174/1570178054405922
Price: $65

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