Synthesis of Azlactones, Phenylpyruvic Acid and 1,2,4-Triazine Derivatives Under Microwave Irradiation

Author(s): E. S.H. El Ashry, E. S. Ramadan, H. A. Hamid, M. Hagar

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 5 , 2005

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Abstract:

Microwave (MW) irradiation has been used in each step for the transformation of acyl glycines 2 to 6-benzyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one (7a), and its 4-phenyl derivatives 7b and 7c. The oxazolone 3a was also transformed to phenylpyruvic acid 5, whose thiosemicarbazone 6 can be cyclized to 7a under MW. Methylation of 7c gave the respective S- and / or N-methylated derivatives, 8 and 9, based on the reaction conditions.

Keywords: microwave, azlactones, triazine, thiosemicarbazone, phenylpyruvic acid

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Article Details

VOLUME: 2
ISSUE: 5
Year: 2005
Page: [415 - 418]
Pages: 4
DOI: 10.2174/1570178054406057
Price: $65

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