Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Azlactones, Phenylpyruvic Acid and 1,2,4-Triazine Derivatives Under Microwave Irradiation

Author(s): E. S.H. El Ashry, E. S. Ramadan, H. A. Hamid and M. Hagar

Volume 2, Issue 5, 2005

Page: [415 - 418] Pages: 4

DOI: 10.2174/1570178054406057

Price: $65

Abstract

Microwave (MW) irradiation has been used in each step for the transformation of acyl glycines 2 to 6-benzyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one (7a), and its 4-phenyl derivatives 7b and 7c. The oxazolone 3a was also transformed to phenylpyruvic acid 5, whose thiosemicarbazone 6 can be cyclized to 7a under MW. Methylation of 7c gave the respective S- and / or N-methylated derivatives, 8 and 9, based on the reaction conditions.

Keywords: microwave, azlactones, triazine, thiosemicarbazone, phenylpyruvic acid


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy