A Facile Synthesis of Chiral Isocyanate-phenol and Unsymmetrical Urea Derived from Tyrosines without Protecting Phenolic Hydroxyl Groups

Author(s): Atsushi Nagai, Bungo Ochiai, Takeshi Endo

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 5 , 2005

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A facile method for synthesis and isolation of chiral isocyanate-phenols, obtained from the reactions of L-tyrosine and L-DOPA [L-3-(3,4-dihydroxyphenyl)alanine] derivatives with di-tert-butyltricarbonate (DBTC), is described. Reaction of the obtained isocyanate-phenol with n-butylamine gave the corresponding chiral unsymmetrical urea.

Keywords: isocyanate, phenol, unsymmetrical, urea, tyrosine, dopa, di-tert-butyltricarbonate

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Article Details

Year: 2005
Page: [404 - 406]
Pages: 3
DOI: 10.2174/1570178054406020
Price: $65

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