Two Novel Lectins from Parkia biglandulosa and Parkia roxburghii: Isolation, Physicochemical Characterization, Mitogenicity and Anti- Proliferative Activity

Author(s): Navjot Kaur, Jatinder Singh, Sukhdev S. Kamboj, Javed N. Agrewala, Manpreet Kaur

Journal Name: Protein & Peptide Letters

Volume 12 , Issue 6 , 2005

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Abstract:

Two mannose/glucose specific seed lectins were isolated from Parkia biglandulosa and Parkia roxburghii and were characterized w.r.t various physicochemical properties. Unlike other Parkia lectins a comparison of native and subunit molecular mass showed that both Parkia lectins were heterotetramers. Parkia biglandulosa lectin was found to be T-cell mitogen as revealed by IL-2 bioassay. These lectins showed anti-proliferative effect on two murine macrophage cancer cell lines i.e. P 388DI (50%) and J774 (70%). In addition Parkia roxburghii also inhibited proliferation of HB98 (65.47%), a B-cell hybridoma cell line.

Keywords: anti-proliferative, cell lines, lectin, leguminosae, mannose, mitogenic, parkia

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Article Details

VOLUME: 12
ISSUE: 6
Year: 2005
Page: [589 - 595]
Pages: 7
DOI: 10.2174/0929866054395725
Price: $65

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