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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of 2,3,4-Trisubstituted Chromans Via Nucleophilic Addition of N-, C-, and SNucleophiles to 3-Nitro-2-Trihalomethyl-2H-Chromenes. Stereochemical and Conformational Preferences

Author(s): V. Y. Korotaev, V. Y. Sosnovskikh, I. B. Kutyashev and M. I. Kodess

Volume 2, Issue 7, 2005

Page: [616 - 620] Pages: 5

DOI: 10.2174/157017805774297000

Price: $65

Abstract

Reactions of N-, C-, and S-nucleophiles with 3-nitro-2-trifluoro(or trichloro)methyl-2H-chromenes proceeded via nucleophilic addition at the double bond to give 2,3,4-trisubstituted chromans in good to moderate yields. Stereochemical and conformational preferences of 2,3,4-trisubstituted chromans were studied.

Keywords: nitro- h-chromenes, s-nucleophiles, nucleophilic addition, trisubstituted chromans


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