Abstract
We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.
Keywords: uracil-dna glycosylase, uracil-dna glycosylase inhibitor, protein transduction, melanoma
Letters in Drug Design & Discovery
Title: Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor
Volume: 2 Issue: 2
Author(s): Maria E. Ariza, Irene Pedersen and M. V. Williams
Affiliation:
Keywords: uracil-dna glycosylase, uracil-dna glycosylase inhibitor, protein transduction, melanoma
Abstract: We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.
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Cite this article as:
Ariza E. Maria, Pedersen Irene and Williams V. M., Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor, Letters in Drug Design & Discovery 2005; 2 (2) . https://dx.doi.org/10.2174/1570180053175179
DOI https://dx.doi.org/10.2174/1570180053175179 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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