One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite

Title: One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite

Volume: 2 Issue: 6

Author(s): H. El Badaoui, F. Bazi, S. Sokori, S. Boulaajaj, H. B. Lazrek and S. Sebti

Affiliation:

Keywords: biginelli reaction, heterogeneous catalysis, dihydropyrimidinones, hydroxyapatite, lewis acids

Abstract: Hydroxyapatite doped with ZnCl2, CuCl2, NiCl2 and CoCl2 efficiently catalyses the three components Biginelli reaction between an aldehyde, ethyl acetoacetate and urea in refluxing toluene to afford the corresponding dihydropyrimidinones in high yields.

Cite this article as:

El Badaoui H., Bazi F., Sokori S., Boulaajaj S., Lazrek B. H. and Sebti S., One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite, Letters in Organic Chemistry 2005; 2 (6) . https://dx.doi.org/10.2174/1570178054640750