Retinoids as Therapeutic Agents: Today and Tomorrow

Author(s): Valerie Vivat-Hannah, F. Christopher Zusi

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 8 , 2005

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Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.

Keywords: rar, rxr, transcription factors, cancer, skin, type II diabetes, retinoids, rexinoids

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Article Details

Year: 2005
Page: [755 - 760]
Pages: 6
DOI: 10.2174/1389557054553820
Price: $65

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PDF: 7