Recent Advances in the Synthesis of C-oligosaccharides

Author(s): Xuejun Yuan, Robert J. Linhardt

Journal Name: Current Topics in Medicinal Chemistry

Volume 5 , Issue 14 , 2005

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This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, Coligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.

Keywords: Cross-aldol reaction, Nitro Stabilized Anions, halogenation-RBR, samariumn species, Ganglioside, exo-glycal

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Article Details

Year: 2005
Page: [1393 - 1430]
Pages: 38
DOI: 10.2174/156802605774643033
Price: $65

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