Celiac Disease: An Emerging Epidemic

Author(s): Peter H.R. Green, Anne R. Lee

Journal Name: Current Nutrition & Food Science

Volume 1 , Issue 3 , 2005

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Celiac disease is a genetically determined autoimmune disorder induced by an environmental agent, gluten. The disease involves the development of a T-cell mediated inflammatory reaction to ingested gluten in the small intestine that results in villous atrophy. The manifestations of the disease are varied. Patients may be critically ill due to a severe malabsorption syndrome or asymptomatic. The reason for the varied phenotypic expression of the disease is unclear. The mainstay of therapy is a gluten-free diet that may be a testing endeavor in this culture.

Keywords: gluten sensitive enteropathy, HLA-DQ2, IgA endomysial antibody, gluten-free diet, autoimmune diseases, Selective IgA deficiency

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Article Details

Year: 2005
Page: [245 - 251]
Pages: 7
DOI: 10.2174/157340105774574811
Price: $65

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