Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives

Author(s): Jose M. Padron, David Tejedor, Alicia Santos-Exposito, Fernando Garcia-Tellado, Jesus Villar, Victor S. Martin

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 7 , 2005


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Abstract:

A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D and MCF7.

Keywords: Pyrroles, diversity-oriented synthesis, privileged structure, breast cancer, SU11248, tyrosine kinase inhibitors

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Article Details

VOLUME: 2
ISSUE: 7
Year: 2005
Published on: 01 March, 2012
Page: [529 - 532]
Pages: 4
DOI: 10.2174/157018005774479122
Price: $65

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