Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships

Author(s): Sarah R. Dennison, James Wallace, Frederick Harris, David A. Phoenix

Journal Name: Protein & Peptide Letters

Volume 12 , Issue 1 , 2005

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To facilitate microbial membrane invasion, amphiphilic α-helical antimicrobial peptides (α-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the α-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.

Keywords: antimicrobial peptides, amphiphilicity, microbial membranes

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Article Details

Year: 2005
Page: [31 - 39]
Pages: 9
DOI: 10.2174/0929866053406084

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