Immunomodulatory Properties of Synthetic Imidazolone Derivatives

Author(s): M. A. Mesaik, K. M. Khan, S. Rahat, Zia-Ullah Zia-Ullah, M. I. Choudhary, S. Murad, N. R. Abdullah, Atta-ur-Rahman Atta-ur-Rahman, A. Ahmad, R. A. Siddiqui

Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 6 , 2005

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Thirteen imidazolone derivatives were synthesized and characterized by 1H NMR, EI, IR and UV spectroscopic and CHN analysis. Among the compounds tested, two compounds, 3-hydroxy-2-phenyl-5-[Ephenylmethylidene]- 3,5-dihydro-4H-imidazol-4-one (12) and 4-[E-(5-methyl-2-furyl) methylidene]-1,2- diphenyl-1H-imidazol-5-one (13) shown to have suppressing activities on the oxidative burst of neutrophils. These two compounds were then further investigated for their effects on different cellular immune responses including neutrophils, phagocytosis and chemotaxis activities of T-cell proliferation, and cytokine production from mononuclear cells. The results demonstrate that compounds 12 and 13 inhibit reactive oxygen species (ROS) generation and phytohemagglutinin (PHA)-induced T-cell proliferation in a dose dependent manner.

Keywords: imidazolone derivative, immunomodulation, cell proliferation, oxidative burst, chemotaxis

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Article Details

Year: 2005
Page: [490 - 496]
Pages: 7
DOI: 10.2174/1570180054771554
Price: $65

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