Abstract
5,6-Dihydroxypyrimidine-4-carboxylic acids are a promising series of hepatitis C virus (HCV) NS5B polymerase inhibitors that bind at the active site of the enzyme. Here we report the evolution and SAR of a series of 2-{2-[(arylsulfonyl)amino]phenyl analogues that show greater than 2 orders of magnitude improved activity over the original lead.
Keywords: hcv, ns5b polymerase, inhibitors, phenyldihydroxypyrimidines, sulfonamides
Letters in Drug Design & Discovery
Title: Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides
Volume: 2 Issue: 6
Author(s): S. Ponzi, C. Giuliano, M. Donghi, M. Poma, V. G. Matassa and I. Stansfield
Affiliation:
Keywords: hcv, ns5b polymerase, inhibitors, phenyldihydroxypyrimidines, sulfonamides
Abstract: 5,6-Dihydroxypyrimidine-4-carboxylic acids are a promising series of hepatitis C virus (HCV) NS5B polymerase inhibitors that bind at the active site of the enzyme. Here we report the evolution and SAR of a series of 2-{2-[(arylsulfonyl)amino]phenyl analogues that show greater than 2 orders of magnitude improved activity over the original lead.
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Cite this article as:
Ponzi S., Giuliano C., Donghi M., Poma M., Matassa G. V. and Stansfield I., Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides, Letters in Drug Design & Discovery 2005; 2 (6) . https://dx.doi.org/10.2174/1570180054771527
DOI https://dx.doi.org/10.2174/1570180054771527 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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