Cross-Metathesis: Efficient Preparation of Trialkyl-Substituted Isoprenoid Olefins as Key-Intermediates for Tocopherol Synthesis

Author(s): Thomas Netscher

Journal Name: Current Topics in Medicinal Chemistry

Volume 5 , Issue 15 , 2005

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Abstract:

A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.

Keywords: Ruthenium-catalysis, tocopherols, isoprenoids, E/Z selectivity, homo-coupling

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Article Details

VOLUME: 5
ISSUE: 15
Year: 2005
Page: [1579 - 1585]
Pages: 7
DOI: 10.2174/156802605775009775
Price: $65

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