The Impact of Lipophilicity in Drug Research: A Case Report on ß-Blockers

Author(s): Raimund Mannhold

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 2 , 2005

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The key importance of lipophilicity in bio-studies is discussed for ß-blockers. Examples of their lipophilicity-dependent pharmacological properties including pharmacokinetic, pharmacodynamic and clinical aspects are reviewed. Comprehensive lipophilicity compilations of ß-blockers are lacking so far. LogP calculations with 10 programs for 30 clinically relevant ß-blockers are presented for the first time in this review.

Keywords: blockers, pharmacokinetic, pharmacodynamic and clinical properties, lipophilicity, logp calculation programs, logp compilation for ß-blockers

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Article Details

Year: 2005
Page: [197 - 205]
Pages: 9
DOI: 10.2174/1389557053402701
Price: $65

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PDF: 16