Multidrug Transporters in Lactic Acid Bacteria

Author(s): P. Mazurkiewicz, K. Sakamoto, G. J. Poelarends, W. N. Konings

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 2 , 2005


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Abstract:

Gram-positive lactic acid bacteria possess several Multi-Drug Resistance systems (MDRs) that excrete out of the cell a wide variety of mainly cationic lipophilic cytotoxic compounds as well as many clinically relevant antibiotics. These MDRs are either proton / drug antiporters belonging to the major facilitator superfamily of secondary transporters or ATP-dependent primary transporters belonging to the ATPbinding cassette superfamily of transport proteins. Here we summarize the existing data on these MDRs and discuss recent observations that suggest the use of new strategies in the ongoing battle against drug-resistant microbial pathogens.

Keywords: multidrug resistance, lactococcus lactis, lactobacillus brevis, antibiotic resistance, excretion, secondary transporters, abc-transporters

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2005
Page: [173 - 181]
Pages: 9
DOI: 10.2174/1389557053402675
Price: $65

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