Photoaffinity Labeling of P-Glycoprotein

Author(s): Michael Peer, Edina Csaszar, Elisabeth Vorlaufer, Stephan Kopp, Peter Chiba

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 2 , 2005

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The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.

Keywords: multidrug resistance, p-glycoprotein, affinity labeling

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Article Details

Year: 2005
Page: [165 - 172]
Pages: 8
DOI: 10.2174/1389557053402738
Price: $65

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