Title: Peroxisome Proliferator-Activated Receptor Agonists as Potential Therapeutic Agents in Multiple Sclerosis
VOLUME: 7 ISSUE: 11
Author(s):Masaaki Niino
Affiliation:Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku,Sapporo, 060-8638, Japan.
Keywords:PPAR, multiple sclerosis, experimental autoimmune encephalomyelitis, cytokine, inflammation
Abstract: Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for gene regulation in glucose and lipid metabolism. It has been recently implicated that PPARs regulate cellular proliferation and inflammatory responses; some agonists for PPARs ameliorate experimental autoimmune encephalomyelitis, a model of multiple sclerosis (MS) in humans. This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS.
