Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates

Author(s): Carolina D. Duarte, Eliezer J. Barreiro, Carlos A.M. Fraga.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 11 , 2007

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Abstract:

Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.

Keywords: Privileged structures, pharmacophoric point, rational drug design, bioactive N-acylhydrazones derivatives

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Article Details

VOLUME: 7
ISSUE: 11
Year: 2007
Page: [1108 - 1119]
Pages: 12
DOI: 10.2174/138955707782331722
Price: $65

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