Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1

Author(s): Maria A. Bednarek

Journal Name: Current Topics in Medicinal Chemistry

Volume 7 , Issue 15 , 2007

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Abstract:

The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents.

Keywords: Melanin-concentrating hormone, melanin-concentrating hormone receptor, antagonist, obesity

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Article Details

VOLUME: 7
ISSUE: 15
Year: 2007
Page: [1425 - 1432]
Pages: 8
DOI: 10.2174/156802607782194734
Price: $65

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