Title: Depsipeptide (FK228) as a Novel Histone Deacetylase Inhibitor: Mechanism of Action and Anticancer Activity
VOLUME: 7 ISSUE: 10
Author(s):Ewa Lech-Maranda, Ewa Robak, Anna Korycka and Tadeusz Robak
Affiliation:Department of Hematology,Medical University of Lodz, Copernicus Hospital, Ciolkowskiego 2 st, 93-510 Lodz, Poland.
Keywords:Epigenetic therapy, histone deacetylase inhibitors, depsipeptide (FK228), cutaneous T-cell lymphoma, solid tumors
Abstract: Depsipeptide (FK228), a new histone deacetylase inhibitor, has been recently introduced into clinical trials. This agent shows interesting metabolic properties, novel mechanism of action, and is undergoing phase I-II clinical studies in hematopoietic malignancies and solid tumors. Mechanism of action, pharmacokinetics and anticancer activity of depsipeptide is the subject of this review.
