High-Speed Screening and Quantitative SAR Analysis of Human ABC Transporter ABCG2 for Molecular Modeling of Anticancer Drugs to Circumvent Multidrug Resistance

Author(s): H. Saito, H. Hirano, T. Ishikawa

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 10 , 2007

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The transport mechanism-based molecular design strategy would provide an effective tool for rationalized chemotherapy against tumors. To develop a platform for molecular modeling to circumvent multidrug resistance, we established new methods of high-speed screening for human ABCG2-drug interactions, quantitative structure-activity relationship (QSAR) analysis, and quantum chemical calculation for lead optimization.

Keywords: ABC transporter, ABCG2, BCRP, camptothecin, high-throughput screening, irinotecan, multidrug resistance, QSAR analysis

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Article Details

Year: 2007
Page: [1009 - 1018]
Pages: 10
DOI: 10.2174/138955707782110169
Price: $65

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