Title: Sphingolipid Signaling Pathways as Potential Therapeutic Targets in Gliomas
VOLUME: 7 ISSUE: 10
Author(s):James R. Van Brocklyn
Affiliation:Division of Neuropathology,Department of Pathology, The Ohio State University, 4164 Graves Hall, 333 W. 10th Ave., Columbus, OH 43210, USA.
Keywords:Glioma, glioblastoma multiforme, sphingolipids, sphingosine-1-phosphate, ceramide
Abstract: Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and S1P leading to cell survival, proliferation and invasion. This review will examine the effects of ceramide and S1P on glioma cells and the therapeutic potential of these pathways.
