Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Series of 4-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of 17α-Hydroxylase/17,20-Lyase (P45017α)

Author(s): Caroline P. Owen, Sachin Dhanani, Chirag H. Patel, Sabbir Ahmed

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

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We report the preliminary results into the synthesis and evaluation of triazole-based compounds against the components of 17α-hydroxylase/17,20-lyase (P45017α), namely 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase). The results show that the compounds are weaker than ketoconazole but are good lead compounds in the search for inhibitors of P45017α, in particular, lyase.

Keywords: 17α-hydroxylase, 17,20-lyase, P45017α, Synthesis, Evaluation, Triazole

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Article Details

Year: 2007
Page: [479 - 483]
Pages: 5
DOI: 10.2174/157018007781788471
Price: $65

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PDF: 5