Title: Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents
VOLUME: 4 ISSUE: 7
Author(s):Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz Lopez, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi and Jan Balzarini
Affiliation:Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy.
Keywords:Microwave, Thiazole, Anticancer agents
Abstract: The microwave-promoted cyclization method has been used for the synthesis of a series of novel substituted 2,4-diarylthiazoles from α-halo ketones and thioamides using ethanol as solvent. This rapid method produces compounds in good yield within one minute in comparison with conventional heating method. The synthesized molecules have been evaluated for their antiproliferative effects against five different cancer cell lines.
