Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents

Romeo, Romagnoli; Pier,Giovanni Baraldi; Olga,Cruz Lopez; Maria,Dora Carrion; Carlota,Lopez Cara; Delia, Preti; Mojgan,Aghazadeh Tabrizi; Jan, Balzarini

Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents

Author(s): Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz Lopez, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini

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Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

DOI : 10.2174/157018007781788507

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Abstract:

The microwave-promoted cyclization method has been used for the synthesis of a series of novel substituted 2,4-diarylthiazoles from α-halo ketones and thioamides using ethanol as solvent. This rapid method produces compounds in good yield within one minute in comparison with conventional heating method. The synthesized molecules have been evaluated for their antiproliferative effects against five different cancer cell lines.

Keywords: Microwave, Thiazole, Anticancer agents

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Letters in Drug Design & Discovery

Title: Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents

VOLUME: 4 ISSUE: 7

Author(s):Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz Lopez, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi and Jan Balzarini

Affiliation:Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy.

Keywords:Microwave, Thiazole, Anticancer agents

Abstract: The microwave-promoted cyclization method has been used for the synthesis of a series of novel substituted 2,4-diarylthiazoles from α-halo ketones and thioamides using ethanol as solvent. This rapid method produces compounds in good yield within one minute in comparison with conventional heating method. The synthesized molecules have been evaluated for their antiproliferative effects against five different cancer cell lines.

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Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz Lopez, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi and Jan Balzarini, “ Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents”, Letters in Drug Design & Discovery (2007) 4: 464. https://doi.org/10.2174/157018007781788507

DOI https://doi.org/10.2174/157018007781788507	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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VOLUME: 4
ISSUE: 7
Year: 2007

Page: [464 - 466]
Pages: 3
DOI: 10.2174/157018007781788507
Price: $65

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