Pigment Epithelium-Derived Factor (PEDF) Prevents Advanced Glycation End Products (AGEs)-Elicited Endothelial Nitric Oxide Synthase (eNOS) Reduction Through Its Anti-Oxidative Properties

Author(s): Sho-ichi Yamagishi, Seiji Ueda, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Masayoshi Takeuchi, Seiya Okuda

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 8 , 2007

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PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.

Keywords: AGEs, eNOS, oxidative stress, PEDF, peroxynitrite

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Article Details

Year: 2007
Page: [832 - 835]
Pages: 4
DOI: 10.2174/092986607781483705
Price: $65

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