Preparation and Biological Activities of Heteroarotinoids

Author(s): Akimori Wada, Yukari Mizuguchi, Hiromi Miyake, Miki Niihara, Masayoshi Ito, Kimie Nakagawa, Toshio Okano

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 6 , 2007

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Retinoic acid analogs containing an aromatic ring fixed between the 5 and 8 positions of retinoic acid, were synthesized by a palladium-catalyzed cross-coupling reaction between boronic acid and an alkenyltriflate or alkenyliodide. The biological activities of the retinoic acid analogs were evaluated.

Keywords: Heteroarotinoid, Boronic acid, Coupling reaction, RAR, RXR

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Article Details

Year: 2007
Page: [442 - 445]
Pages: 4
DOI: 10.2174/157018007781387827
Price: $65

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