Preparation and Biological Activities of Heteroarotinoids

Title: Preparation and Biological Activities of Heteroarotinoids

Volume: 4 Issue: 6

Author(s): Akimori Wada, Yukari Mizuguchi, Hiromi Miyake, Miki Niihara, Masayoshi Ito, Kimie Nakagawa and Toshio Okano

Affiliation:

Keywords: Heteroarotinoid, Boronic acid, Coupling reaction, RAR, RXR

Abstract: Retinoic acid analogs containing an aromatic ring fixed between the 5 and 8 positions of retinoic acid, were synthesized by a palladium-catalyzed cross-coupling reaction between boronic acid and an alkenyltriflate or alkenyliodide. The biological activities of the retinoic acid analogs were evaluated.

Cite this article as:

Akimori Wada , Yukari Mizuguchi , Hiromi Miyake , Miki Niihara , Masayoshi Ito , Kimie Nakagawa and Toshio Okano , Preparation and Biological Activities of Heteroarotinoids, Letters in Drug Design & Discovery 2007; 4 (6) . https://dx.doi.org/10.2174/157018007781387827