A self-organizing map (SOM) was used for identification of synthetic tripeptides to HIV-1 TAR-RNA. This virtual screening strategy identified a phenanthrene-Arg-Arg sequence with an IC50 value of 5 μM. The SOM technique was shown to be applicable to RNA-ligand finding following an entirely ligand-based approach.
Keywords: Neural network, Peptide, SOM, Kohonen network, Virtual screening, Docking
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