Abstract
An excessive production of oxidants disturbs the normal intracellular equilibrium, and can lead to an “oxidative stress”. Recent data indicate that several components of the regular diet as well as chemical compounds and drugs can modulate the so-called “oxidative stress” both via anti-oxidant effects and via inhibition or activation of the enzymes involved in reactive nitrogen oxygen species (RNOS). We will describe in this review article the biochemistry of oxygen, the physiological roles and regulation of oxidative stress. The clinical relevance of uncontrolled oxidative stress will be presented as well as the results of therapeutic trials with antioxidants. New promising strategies which modulate the activities of the RNOS generating enzymes, with selected catalytic inhibitors will be discussed.
Keywords: Oxidative stress, oxidants, reactive nitrogen oxygen species, anti-oxidants
Current Nutrition & Food Science
Title: How to Keep Oxidative Stress Under Control?
Volume: 3 Issue: 3
Author(s): Laetitia Pire, Ginette Deby-Dupont, Thierry Lemineur and Jean-Charles Preiser
Affiliation:
Keywords: Oxidative stress, oxidants, reactive nitrogen oxygen species, anti-oxidants
Abstract: An excessive production of oxidants disturbs the normal intracellular equilibrium, and can lead to an “oxidative stress”. Recent data indicate that several components of the regular diet as well as chemical compounds and drugs can modulate the so-called “oxidative stress” both via anti-oxidant effects and via inhibition or activation of the enzymes involved in reactive nitrogen oxygen species (RNOS). We will describe in this review article the biochemistry of oxygen, the physiological roles and regulation of oxidative stress. The clinical relevance of uncontrolled oxidative stress will be presented as well as the results of therapeutic trials with antioxidants. New promising strategies which modulate the activities of the RNOS generating enzymes, with selected catalytic inhibitors will be discussed.
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Cite this article as:
Laetitia Pire , Ginette Deby-Dupont , Thierry Lemineur and Jean-Charles Preiser , How to Keep Oxidative Stress Under Control?, Current Nutrition & Food Science 2007; 3 (3) . https://dx.doi.org/10.2174/157340107781369143
DOI https://dx.doi.org/10.2174/157340107781369143 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
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