Regioselective Synthesis of Biologically Important Scaffold Spiro [Indole- Perimidines]: An Antitumor Agents

Author(s): Kapil Arya, Anshu Dandia

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 5 , 2007

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Regioselective synthesis of spiro [indole -3(3H), 2 (3H)perimidine]2(1H)one (4a-e) for potential application in cancer treatment under conventionally and microwave irradiation using different solvents/solid support has been studied. A judicious choice of the reaction conditions allowed the titled product 4a-e to be generated in excellent yields.

Keywords: Perimidine, indole 2,3-dione, microwave, 1,8-diaminonapthalene, montmorillonite KSF, cytotoxic

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Article Details

Year: 2007
Page: [378 - 383]
Pages: 6
DOI: 10.2174/157017807781212175
Price: $65

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