Title: Syntheses of the Ammonium Salts of 7-Carbamate Derivatives of Quercetin
VOLUME: 4 ISSUE: 5
Author(s): Chenglong Wu, Li Cheng, Ying Li, Dong Guo, Shuyan Yu, Xianxue Wu and Yuquan Wei
Affiliation:Key Laboratory of Drug Targeting of Ministry of National Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Keywords:Quercetin, 7-carbamate derivatives of quercetin, dichlorodiphenylmethane, isocyanate, ammonium salt
Abstract: A series of 7-carbamate derivatives of quercetin were synthesized. Using dichlorodiphenylmethane and benzyl bromide to partly protect the hydroxyl groups, the protected quercetin then reacted with amino acid ester isocyanates, deprotection the hydroxyls with hydrogen using a palladium on carbon catalyst, then treating with ammonia gas to give the ammonium salts of 7-carbamate derivatives of quercetin.
