Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors

Author(s): Seiichiro Ogawa, Miki Kanto, Yoshiyuki Suzuki, Seiichiro Ogawa, Miki Kanto, Yoshiyuki Suzuki

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 7 , 2007

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This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-??-valienamine as a lysosomal ??-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human ??-galactosidase deficiency disorder, GM1-gangliosidosis.

Keywords: Carbasugars, aminocyclitols, 5a-carbaglycosylamines, glycosidase inhibitors, chemical chaperone therapy, lysosomal disease, GM1-gangliosidosis

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Article Details

Year: 2007
Page: [679 - 691]
Pages: 13
DOI: 10.2174/138955707781024508
Price: $65

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