Statistics of Catalytic Domain Sequences in Protein Kinases Vs Non-Kinases

Author(s): Rajani R. Joshi, Chaithanya Manda

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species? We have attempted analyzing some of these aspects by statistical data mining using an authentic and exhaustive database of Protein Kinases. The results reveal interesting features and provide some new directions to look at their applications.

Keywords: Protein Kinase, Catalytic Sub Domain, Sequence Homology, BLAST, 2-way ANOVA, Statistical Likelihood Estimates

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Article Details

Year: 2007
Page: [518 - 527]
Pages: 10
DOI: 10.2174/092986607780989985
Price: $65

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