CCK Receptors and Cancer

Author(s): Graham S. Baldwin, Arthur Shulkes

Journal Name: Current Topics in Medicinal Chemistry

Volume 7 , Issue 12 , 2007

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Over the past 20 years there has been considerable interest in the role of CCK receptors in gastrointestinal cancer. Initial excitement over reports of the detection by PCR of CCK-1 and CCK-2 receptor mRNA in a wide range of gastrointestinal tumours has been tempered by the realisation that the presence of receptor binding sites is much more restricted. The current consensus is that expression of CCK-1 and -2 receptor proteins is common only in tumours of neural or neuroendocrine origin. A striking example of this general rule has been provided by the detection of CCK-2 receptors by receptor autoradiography in more than 90% of medullary thyroid carcinomas. Despite the absence of CCK receptors from many gastrointestinal adenocarcinomas, evidence from animal models and from tumour cell lines in vitro suggests that the CCK-2 receptor may contribute to the development of esophageal and gastric adenocarcinomas, and further experimental work in these areas is clearly warranted. Promising therapeutic approaches include the development of radiolabelled gastrin/CCK derivatives for use in tumour imaging, and the use of appropriate selective antagonists for treatment of those tumour subtypes likely to express CCK receptors.

Keywords: Cholecystokinin, Colorectal cancer, Gastric cancer, Gastrin, Pancreatic cancer

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Article Details

Year: 2007
Page: [1232 - 1238]
Pages: 7
DOI: 10.2174/156802607780960492
Price: $65

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