Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids

Author(s): Abderrahmane Yahyi, Abdelkader Ettouhami, Smaail Radi, Ismail Zidane, Abdelkader Hakkou, Mohamed Bouakka

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 5 , 2007

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The synthesis of new triphenyltin derivatives with (N-substituted-pyrazol-3-yl) carboxylic acid fragments is described. The in vitro antibacterial activity of the new agents was evaluated against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). A considerable activity was recorded with respect to the three studied micro-organisms. Structure activity relationship studies (SAR) reflect the effect of substituted pyrazolic fragment.

Keywords: Pyrazolic acids, Triphenyltin derivatives, Biological activities

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Article Details

Year: 2007
Page: [382 - 385]
Pages: 4
DOI: 10.2174/157018007780867889
Price: $65

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