Molecular Basis of Agonistic Activity of ERα17p, a Synthetic Peptide Corresponding to a Sequence Located at the N-Terminal Part of the Estrogen Receptor αLigand Binding Domain

Author(s): Dominique Gallo, Yves Jacquot, Anny Cleeren, Francoise Jacquemotte, Ioanna Laios, Guy Laurent, Guy Leclercq

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 5 , 2007

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ERα17p is a synthetic peptide corresponding to a regulatory motif located within the autonomous AF-2a region of the estrogen receptor α (ERα). ERα17p binds to the receptor and enhances its transcriptional activity. Structural characteristics of this peptide suggest that it interferes with intra- and/or interprotein interactions involving ERα.

Keywords: Estrogen Receptor, Synthetic Peptide, ERα17p, Regulatory Motif, AF-2

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Article Details

Year: 2007
Page: [346 - 355]
Pages: 10
DOI: 10.2174/157018007780867807
Price: $65

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