Abstract
Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.
Keywords: S100B, p53, calcium, inhibitors, drug design, cancer
Mini-Reviews in Medicinal Chemistry
Title: A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins
Volume: 7 Issue: 6
Author(s): Joseph Markowitz, Alexander D. MacKerell and David J. Weber
Affiliation:
Keywords: S100B, p53, calcium, inhibitors, drug design, cancer
Abstract: Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.
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Cite this article as:
Joseph Markowitz , Alexander D. MacKerell and David J. Weber , A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins, Mini-Reviews in Medicinal Chemistry 2007; 7 (6) . https://dx.doi.org/10.2174/138955707780859422
DOI https://dx.doi.org/10.2174/138955707780859422 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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